References

Bachour Y, Kadouch JA, Niessen FB. The aetiopathogenesis of late inflammatory reactions (LIRs) after soft tissue filler use: a systematic review of the literature. Aesthetic Plast Surg. 2021; 45:(4)1748-1759 https://doi.org/10.1007/s00266-021-02306-3

Becker K, Heilmann C, Peters G. Coagulasenegative staphlococci. Clin Microbiol Rev.. 2015; 27:(4)870-926 https://doi.org/10.1128/cmr.00109-13

Bjarnsholt T. The role of bacterial biofilms in chronic infections. APMIS Suppl.. 2013; (136)1-51 https://doi.org/10.1111/apm.12099

Cassuto D, Sundaram H. A problem-oriented approach to nodular complications from hyaluronic acid and calcium hydroxylapatite fillers: classification and recommendations for treatment. Plast Reconstr Surg. 2013; 132:48S-58S https://doi.org/10.1097/prs.0b013e31829e52a7

Convery C, Davies E, Murray G, Walker L. Delayed-onset nodules (DONs) and considering their treatment following use of hyaluronic acid (HA) fillers. J Clin Aesthet Dermatol.. 2021; 14:(7)E59-E67

Costerton JW, Montanaro L, Arciola CR. Biofilm in implant infections: its production and regulation. Int J Artif Organs. 2005; 28:(11)1062-1068 https://doi.org/10.1177/039139880502801103

Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science. 1999; 284:(5418)1318-1322 https://doi.org/10.1126/science.284.5418.1318

De Boulle K, Heydenrych I. Patient factors influencing dermal filler complications: prevention, assessment, and treatment. Clin Cosmet Investig Dermatol.. 2015; 8:205-214 https://doi.org/10.2147%2FCCID.S80446

de la Fuente-Núñez C, Reffuveille F, Fernandez L, Hancock REW. Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies. Curr Opin Microbiol.. 2013; 16:(5)580-589 https://doi.org/10.1016/j.mib.2013.06.013

DeLorenzi C. Complications of injectable fillers, part I. Aesthet Surg J.. 2013; 33:(4)561-575 https://doi.org/10.1177/1090820x13484492

Donlan RM. Biofilms and device-associated infections. Emerg Infect Dis.. 2001; 7:(2)277-281 https://doi.org/10.3201/eid0702.010226

El-Khalawany M, Fawzy S, Saied A, Al Said M, Amer A, Eassa B. Dermal filler complications: a clinicopathologic study with a spectrum of histologic reaction patterns. Ann Diagn Pathol.. 2015; 19:(1)10-15 https://doi.org/10.1016/j.anndiagpath.2014.11.004

Graivier MH, Bass LM, Lorenc ZP, Fitzgerald R, Goldberg DJ, Lemperle G. Differentiating nonpermanent injectable fillers: prevention and treatment of filler complications. Aesthet Surg J.. 2018; 38:S29-S40 https://doi.org/10.1093/asj/sjy032

Hoiby N, Ciofu O, Johansen HK The clinical impact of bacterial biofilms. Int J Oral Sci.. 2011; 3:(2)55-65 https://doi.org/10.4248/ijos11026

Ibrahim O, Overman J, Arndt KA, Dover JS. Filler nodules: inflammatory or infectious? A review of biofilms and their implications on clinical practice. Dermatol Surg. 2018; 44:(1)53-60 https://doi.org/10.1097/dss.0000000000001202

O'Toole GA. To build a biofilm. J Bacteriol.. 2003; 185:(9)2687-2689 https://doi.org/10.1128%2FJB.185.9.2687-2689.2003

Rohrich RJ, Monheit G, Nguyen AT, Brown SA, Fagien S. Soft-tissue filler complications: the important role of biofilms. Plast Reconstr Surg. 2010; 125:(4)1250-1256 https://doi.org/10.1097/prs.0b013e3181cb4620

Sharma D, Misba L, Khan AU. Antibiotics versus biofilm: an emerging battleground in microbial communities. Antimicrob Resist Infect Control.. 2019; 8 https://doi.org/10.1186/s13756-019-0533-3

Tolker-Nielson T. Biofilm development. Microbiol Spectr. 2015; 3:(2) https://doi.org/10.1128/microbiolspec.mb-0001-2014

Wagner RD, Fakhro A, Cox JA, Izaddoost SA. Etiology, prevention, and management of infectious complications of dermal fillers. Semin Plast Surg. 2016; 30:(2)83-86 https://doi.org/10.1055/s-0036-1580734

Injectables

Dermal fillers and biofilms: implications for aesthetic clinicians

02 October 2021
Comment
02 October 2021
Volume 10 · Issue 8

Abstract

Biofilms have been linked to dermal filler complications. Gillian Murray and Dr Cormac Convery explain their role and what clinicians can do to identify biofilm, as well as how to manage and treat them

Biofilms pose a significant danger to the body's ability to treat infections. They are able to evade the immune system, tolerate antibiotics and withstand environmental stresses. These factors lead to the development of antibiotic resistance and chronic infection. Biofilms are colonies of bacteria that grow on the surface of medical implanted devices, such as dental implants, joint prosthetics, sutures, catheters and crosslinked hyaluronic acid dermal fillers (Costerton et al, 1999; de la Fuente-Núñez et al, 2013). The concept of biofilm is complex; however, in basic terms, bacteria can either exist in a free planktonic state or develop a communal lifestyle, known as a biofilm. In the latter state, they orchestrate the production of a variety of chemicals, including adhesins and extracellular polymeric substances, that link and encase the bacteria. This cell-to-cell connecting structure is beneficial for bacterial survival. It helps them to communicate, attach to surfaces and, perhaps most importantly, provides a mechanism for resistance to antimicrobial agents (Tolker-Nielson, 2015).

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